Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Anexate, Romazicon
Flumazenil is a benzodiazepine receptor antagonist used to reverse the sedative effects of benzodiazepines. It acts by competitively binding to the benzodiazepine receptor site, thereby inhibiting the action of benzodiazepines. This drug is primarily used in cases of benzodiazepine overdose and to help patients recover from anesthesia induced by benzodiazepines.
Reversal of benzodiazepine sedation, including overdose and anesthesia recovery.
Outcome:
Reduced efficacy of benzodiazepines
Mechanism:
Competitive antagonism
Outcome:
Decreased flumazenil levels
Mechanism:
Enzyme induction
Outcome:
May decrease effectiveness of flumazenil
Mechanism:
Antagonism at adenosine receptors
Most likely new formulation: Extended-release formulation for prolonged reversal of benzodiazepine effects (Year: 2026, 70% confidence)
Based on current usage patterns and adverse event reports, the likelihood of a black box warning being issued for flumazenil in the next 5 years is less than 1%.
Benzodiazepine antagonist
Imidazobenzodiazepine