Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Locacorten, Locorten, Flumethasone Pivalate, Lorinden
Flumethasone is a potent synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It is used topically to treat various skin conditions like eczema, psoriasis, and dermatitis. It belongs to the glucocorticoid class of drugs and works by binding to glucocorticoid receptors in the cytoplasm, ultimately modulating gene expression and affecting various inflammatory pathways.
For the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Outcome:
Increased risk of systemic side effects of flumethasone
Mechanism:
Reduced metabolism of flumethasone
Outcome:
May enhance muscle weakness in patients with myasthenia gravis
Mechanism:
Additive effects on neuromuscular transmission
Outcome:
May slightly decrease absorption of flumethasone
Mechanism:
Changes in stomach pH
Most likely new formulation: Optimized topical delivery systems (2025, 70% confidence)
Based on current usage trends and ongoing clinical trials, there is a low ( <5%) likelihood of a major regulatory change in the next 2 years.
Corticosteroid, Glucocorticoid
Pregna-1,4-diene-3,20-dione derivative