Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Rohypnol, Hypnodorm
Flunitrazepam is a potent benzodiazepine with hypnotic, sedative, anxiolytic, anticonvulsant, and skeletal muscle relaxant properties. It is classified as a nitrobenzodiazepine and is significantly more potent than diazepam. Due to its potency and rapid onset of action, flunitrazepam has a high potential for abuse and is associated with cases of drug-facilitated sexual assault. It is a Schedule IV controlled substance in the United States.
Short-term treatment of insomnia (severe, disabling)
Flunitrazepam has a high potential for abuse and dependence and can cause anterograde amnesia. It has been associated with drug-facilitated sexual assault.
Outcome:
Increased sedation, respiratory depression
Mechanism:
Additive CNS depressant effects
Outcome:
Increased flunitrazepam levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
May slightly decrease the sedative effects of flunitrazepam
Mechanism:
Caffeine is a CNS stimulant
New non-benzodiazepine hypnotics with improved safety profiles are more likely to be developed. (Next 5 years, 80% confidence)
Due to its withdrawal from the US market and the potential for abuse, the likelihood of flunitrazepam being reintroduced or reformulated is extremely low (<1%).
Benzodiazepine, Hypnotic, Sedative
Nitrobenzodiazepine