Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Prolixin, Modecate
Fluphenazine is a typical antipsychotic medication primarily used to treat schizophrenia and other psychotic disorders. It belongs to the phenothiazine class of drugs and works by blocking dopamine receptors in the brain. It is available in various formulations including tablets, capsules, elixir, and a long-acting decanoate injection.
For the treatment of schizophrenia and other psychotic disorders.
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Fluphenazine is not approved for the treatment of patients with dementia-related psychosis.
Outcome:
Increased sedation and dizziness
Mechanism:
Additive CNS depressant effects
Outcome:
Reduced absorption of fluphenazine
Mechanism:
Chelation
Outcome:
Reduced efficacy of fluphenazine
Mechanism:
Antagonism of dopamine blockade
Most likely new formulation: Long-acting injectable with improved tolerability (2025, 30% confidence)
Based on current usage trends and clinical trial data, there is a low ( <5%) likelihood of significant regulatory changes for fluphenazine in the next 5 years.
Antipsychotic, Phenothiazine
Phenothiazine