Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Ansaid, Ocufen, Froben
Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It works by inhibiting the production of prostaglandins, chemicals in the body that cause pain, fever, and inflammation. Flurbiprofen is available in various formulations, including oral tablets, ophthalmic solutions, and topical patches.
For pain, fever, and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and menstrual cramps; also used in ophthalmic solutions for pain and inflammation after eye surgery.
NSAIDs increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. Flurbiprofen is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.
Outcome:
Increased bleeding risk
Mechanism:
Flurbiprofen can displace warfarin from protein binding sites, increasing its free concentration.
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Synergistic effect on gastric mucosa irritation.
Outcome:
Reduced absorption of flurbiprofen
Mechanism:
Antacids can alter gastric pH, affecting drug absorption.
Most likely new formulation: sustained-release topical patch for localized pain management (2025, 70% confidence).
Based on current usage trends and safety profile, flurbiprofen's approval status is likely to remain stable (95% confidence).
NSAID, Propionic Acid Derivative
2-Arylpropionic acid