Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Advair, Seretide, Airduo, Flutiform
Fluticasone/salmeterol is a combination medication used for the long-term maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). Fluticasone is a corticosteroid that reduces inflammation in the airways, while salmeterol is a long-acting beta2-adrenergic agonist (LABA) that relaxes the muscles around the airways, making it easier to breathe. This combination therapy is not intended for the relief of acute bronchospasm.
For long-term maintenance treatment of asthma and COPD.
Increased risk of asthma-related death with LABAs. Use only as an add-on treatment in patients not adequately controlled on other asthma controller medications.
Outcome:
Increased fluticasone levels and risk of systemic corticosteroid effects.
Mechanism:
Inhibition of fluticasone metabolism.
Outcome:
May increase risk of asthma exacerbations in some patients.
Mechanism:
Not fully understood.
Outcome:
May slightly decrease fluticasone absorption.
Mechanism:
Changes in gastric pH.
Most likely new formulation: Improved delivery systems for enhanced efficacy and patient compliance (Year: 2025, 70% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood of significant regulatory changes within the next 5 years.
Corticosteroid, Beta2-adrenergic agonist
Corticosteroid, Saligenin