Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Metafolin, Deplin, Quatrefolic
5-methyltetrahydrofolate (5-MTHF), also known as levomefolic acid or L-methylfolate, is the biologically active form of folate. It is a naturally occurring form of folate, the primary active form in the body, and crucial for various bodily functions, including DNA synthesis, cell division, and the production of red blood cells. Unlike folic acid, which must be converted to 5-MTHF before the body can use it, 5-MTHF can be directly utilized. This is especially important for individuals with certain genetic variations that affect folate metabolism. 5-MTHF is often used as a dietary supplement to address folate deficiency.
For preventing and treating folate deficiency, supporting cell growth and division, and aiding in the formation of red blood cells.
Outcome:
Reduced efficacy of methotrexate
Mechanism:
5-MTHF can interfere with the action of methotrexate.
Outcome:
Decreased folate absorption and utilization
Mechanism:
Alcohol interferes with folate metabolism.
Outcome:
May slightly decrease folate levels
Mechanism:
High doses of aspirin can displace folate from protein binding sites.
Most likely new formulation: Sustained-release 5-MTHF (Year: 2025, 80% confidence)
Based on usage trends and ongoing research, there is a 70% likelihood of expanded indications for 5-MTHF in mental health within the next 5 years.
Vitamin, Folic Acid Analog
Reduced Folate