Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Rukobia
Fostemsavir is an antiviral medication used in the treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1. It's a first-in-class attachment inhibitor, targeting the HIV-1 gp120 protein and preventing the virus from attaching to host cells, thus blocking entry and subsequent replication. Fostemsavir is generally used in combination with other antiretroviral therapies.
Fostemsavir is used in combination with other antiretroviral medications to treat multidrug-resistant HIV-1 infection in heavily treatment-experienced adults.
Outcome:
Reduced fostemsavir levels
Mechanism:
CYP3A4 induction
Outcome:
Increased atazanavir levels
Mechanism:
CYP3A4 inhibition
Outcome:
Reduced fostemsavir absorption
Mechanism:
Chelation/pH alteration
Most likely new formulation: Long-acting injectable formulation (Year: 2025, 70% confidence)
Based on current usage trends and clinical trial data, there is a high likelihood (85%) that fostemsavir will remain a key treatment option for multidrug-resistant HIV-1.
Antiretroviral, Attachment Inhibitor
Phosphonooxymethyl prodrug of temsavir