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Discover all available medicines and treatments
Brand: Muphoran
Fotemustine is an alkylating antineoplastic agent used in the treatment of brain tumors and malignant melanoma. It belongs to the nitrosourea class of drugs and works by interfering with DNA replication and repair in cancer cells, ultimately leading to cell death. It is administered intravenously and is often used in combination with other chemotherapeutic agents.
For the treatment of brain tumors and malignant melanoma.
Severe myelosuppression, including prolonged pancytopenia, may occur. Regular blood count monitoring is essential.
Outcome:
Increased fotemustine toxicity
Mechanism:
Inhibition of fotemustine metabolism
Outcome:
Altered fotemustine metabolism
Mechanism:
Enzyme induction or inhibition
Outcome:
Potential altered absorption
Mechanism:
Delayed gastric emptying
Most likely new formulation: liposomal fotemustine for improved delivery and reduced toxicity (Year 2026, 80% confidence)
Based on current usage trends and clinical trial outcomes, there is a 70% likelihood of expanded indications for fotemustine in other cancer types within the next 5 years.
Alkylating agent, Nitrosourea
Nitrosourea