Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: DaTSCAN
FP-CIT, also known as ioflupane I 123, is a radiopharmaceutical used in nuclear medicine imaging. It is a cocaine analogue that binds to the dopamine transporter (DAT) in the brain. This allows visualization of the striatum, a region rich in dopaminergic neurons, using single-photon emission computed tomography (SPECT). It aids in the differential diagnosis of Parkinsonian syndromes (PS) such as Parkinson’s disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP).
Used for the differential diagnosis of Parkinsonian syndromes (PS).
Outcome:
Competition for DAT binding
Mechanism:
Cocaine binds to DAT
Outcome:
May interfere with imaging results
Mechanism:
Competition for DAT binding sites
Outcome:
Potential for mild interaction
Mechanism:
Weak dopamine reuptake inhibitor
Development of new DAT imaging agents with improved properties (e.g., higher affinity, longer half-life) is likely within the next 5-10 years (70% confidence).
Based on current usage trends and clinical trial activity, FP-CIT is expected to maintain its role as a key diagnostic tool for Parkinsonian syndromes.
Radiopharmaceutical, Diagnostic Agent
Tropane Derivative