Medicines
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Brand: Gadavist
Gadobutrol is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to enhance the visibility of internal organs, blood vessels, and tissues. It belongs to the class of macrocyclic, non-ionic contrast media and works by shortening the T1 relaxation time of water protons in the body, leading to brighter images in T1-weighted MRI scans. This improved contrast helps radiologists better detect and characterize various abnormalities, including tumors, inflammation, and vascular diseases.
Used to enhance visualization of body structures during MRI scans.
Outcome:
Increased risk of nephrogenic systemic fibrosis (NSF) in patients with impaired renal function.
Mechanism:
Additive renal toxicity.
Outcome:
Reduced absorption of gadobutrol.
Mechanism:
Chelation of gadolinium by iron.
Outcome:
May slightly delay absorption.
Mechanism:
Delayed gastric emptying.
Most likely new formulation: Higher concentration formulation for improved image quality (Year: 2026, 70% confidence)
Based on current usage trends and safety profile, gadobutrol is expected to maintain its approved status with a 95% likelihood for the next 5 years.
MRI Contrast Agent, Gadolinium-based Contrast Agent
Macrocyclic Gadolinium Chelate