Medicines
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Brand: Omniscan, OptiMARK
Gadodiamide is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to enhance the visibility of internal organs, blood vessels, and tissues. It belongs to the class of linear, ionic, non-specific extracellular contrast agents. It works by shortening the T1 relaxation time of water protons in the body, making certain areas appear brighter on MRI scans. This increased contrast helps radiologists better differentiate between normal and abnormal tissues.
Used to enhance the visibility of internal organs, blood vessels, and tissues during MRI scans.
Gadolinium-based contrast agents (GBCAs) increase the risk of nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate <30 mL/min/1.73m2) and in patients with acute renal failure of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period. Screen patients for renal function by obtaining a history and/or laboratory tests. Do not administer Omniscan to patients with severe renal impairment. Avoid Omniscan in patients with acute or chronic severe renal insufficiency (GFR < 30 mL/min/1.73m2) and patients with acute kidney injury unless the diagnostic information is essential and not available with non-contrast enhanced MRI.
Outcome:
Increased risk of kidney damage
Mechanism:
Additive nephrotoxicity
Outcome:
Increased risk of lactic acidosis in patients with renal impairment
Mechanism:
Reduced metformin excretion
Outcome:
Potential for reduced absorption of gadodiamide
Mechanism:
Chelation of gadolinium
Most likely new formulation: Chelated gadolinium with improved safety profile (Year: 2026, 75% confidence)
Based on current usage trends and safety profile, gadodiamide is likely to remain approved for MRI enhancement, but with continued emphasis on renal safety screening (90% confidence).
MRI Contrast Agent, Gadolinium-based Contrast Agent
Gadolinium Chelate