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Brand: Magnevist, MultiHance, Omniscan, OptiMARK, ProHance
Gadolinium is a rare earth metal element used as a contrast agent in magnetic resonance imaging (MRI) scans. It works by altering the magnetic properties of nearby water molecules, enhancing the clarity and detail of the images. Gadolinium itself is toxic, so it is administered as a chelated compound, bound to a molecule that allows it to be safely cleared from the body by the kidneys. While generally considered safe, some gadolinium-based contrast agents (GBCAs) have been associated with the development of nephrogenic systemic fibrosis (NSF) in patients with severe kidney disease.
Used as a contrast agent to enhance magnetic resonance imaging (MRI) scans.
Outcome:
Increased risk of nephrogenic systemic fibrosis (NSF)
Mechanism:
Reduced renal clearance of gadolinium.
Outcome:
Reduced effectiveness of iron therapy
Mechanism:
Gadolinium may interfere with iron absorption.
Outcome:
Slightly reduced absorption of gadolinium
Mechanism:
Changes in stomach pH
Most likely new formulation: Chelated gadolinium with improved renal clearance and reduced NSF risk (Year: 2028, 70% confidence)
Based on current usage trends and safety profiles, there is a low (<5%) likelihood of major regulatory changes for approved GBCAs in the next 5 years.
Contrast Agent
Lanthanide