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Brand: Gadovist, Gadograf
Gadobutrol is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to enhance the visibility of internal organs, blood vessels, and tissues. It belongs to the class of macrocyclic, non-ionic contrast media and works by shortening the T1 relaxation time of water protons in the body, leading to brighter images in T1-weighted MRI scans. This helps in better visualization of lesions and abnormalities.
Used to enhance the visibility of internal organs, blood vessels, and tissues during magnetic resonance imaging (MRI) scans.
Outcome:
Increased risk of nephrogenic systemic fibrosis (NSF)
Mechanism:
Additive renal toxicity
Outcome:
Increased risk of lactic acidosis
Mechanism:
Reduced renal clearance of metformin
Outcome:
Reduced absorption of gadobutrol
Mechanism:
Chelation
Most likely new formulation: Higher concentration formulation for improved image quality (2025, 70% confidence).
Based on current usage trends and safety profile, gadobutrol is expected to maintain its approved status with minimal regulatory changes (95% confidence).
MRI Contrast Agent, Gadolinium-based Contrast Agent
Gadolinium Chelate