Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Gemzar
Gemcitabine is a nucleoside analog antimetabolite used in chemotherapy. It's a pyrimidine analog, meaning it disrupts DNA synthesis, preventing cancer cells from dividing and growing. It's often used in combination with other chemotherapeutic agents for various cancers like pancreatic, lung, bladder, and breast cancer.
Used to treat various cancers including pancreatic, lung, bladder, breast, and ovarian cancer, often in combination with other chemotherapeutic agents.
Myelosuppression (bone marrow suppression), pulmonary toxicity (including pulmonary edema and adult respiratory distress syndrome), hepatic (liver) toxicity including veno-occlusive disease, renal (kidney) toxicity, and capillary leak syndrome.
Outcome:
Increased risk of radiation recall reactions (skin inflammation)
Mechanism:
Gemcitabine can sensitize cells to radiation.
Outcome:
Increased risk of bleeding
Mechanism:
Both drugs can affect platelet function.
Outcome:
Reduced gemcitabine absorption
Mechanism:
Antacids may affect drug absorption.
Most likely new formulation: Liposomal gemcitabine (2025, 60% confidence)
Based on ongoing clinical trials and emerging research, there is a 70% likelihood of expanded indications for gemcitabine in combination therapies within the next 5 years.
Antineoplastic, Antimetabolite, Pyrimidine Analog
Nucleoside Analog