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Discover all available medicines and treatments
Brand: Garamycin, Gentak, Genoptic, Septopal
Gentamicin is an aminoglycoside antibiotic used to treat serious bacterial infections, particularly those caused by Gram-negative bacteria. It works by inhibiting bacterial protein synthesis, leading to bacterial cell death. Gentamicin is typically administered intravenously or intramuscularly and is reserved for infections that are resistant to other antibiotics due to its potential for serious side effects.
For treatment of serious bacterial infections, especially Gram-negative infections.
Gentamicin can cause serious kidney damage (nephrotoxicity) and hearing loss (ototoxicity), including irreversible deafness. Patients should be closely monitored for these side effects.
Outcome:
Increased risk of nephrotoxicity
Mechanism:
Additive renal toxicity
Outcome:
Increased risk of nephrotoxicity
Mechanism:
Additive nephrotoxicity
Outcome:
Reduced gentamicin absorption
Mechanism:
Chelation
Most likely new formulation: Liposomal gentamicin for reduced toxicity (2026, 70% confidence)
Based on increasing bacterial resistance patterns, the use of gentamicin is expected to remain stable with a 10% increase in targeted therapies by 2025.
Aminoglycoside Antibiotic
Aminoglycoside