Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Intuniv, Tenex
Guanfacine is a selective alpha2A-adrenergic receptor agonist primarily used to treat attention-deficit/hyperactivity disorder (ADHD) and high blood pressure (hypertension). It works by affecting the activity of certain nerve cells in the brain, specifically in the prefrontal cortex, which plays a vital role in attention, planning, and impulse control. For ADHD, it's often used when stimulants are ineffective or cause intolerable side effects. For hypertension, it can be used alone or in combination with other antihypertensive medications.
For attention-deficit/hyperactivity disorder (ADHD) and high blood pressure (hypertension).
Outcome:
Increased sedation and dizziness.
Mechanism:
Additive CNS depressant effects.
Outcome:
Additive bradycardia and hypotension.
Mechanism:
Synergistic effects on heart rate and blood pressure.
Outcome:
May decrease the effectiveness of guanfacine.
Mechanism:
Caffeine is a stimulant.
Most likely new formulation: Extended-release transdermal patch (Year 2025, 80% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of expanded indications for guanfacine in the treatment of related neurological conditions within the next 5 years.
Centrally Acting Alpha2-Adrenergic Agonist, Antihypertensive
Guanidine derivative