Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Generic: Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
Used in the diagnosis of achlorhydria and to assess the capacity of the gastric mucosa to secrete acid.
Outcome:
Respiratory depression and excessive sedation.
Mechanism:
Additive CNS depression.
Outcome:
Increased drowsiness and sedation.
Mechanism:
Alcohol can potentiate the sedative effects of histamine.
Outcome:
Potential for reduced bronchodilation.
Mechanism:
Beta-blockers may oppose the bronchodilatory effects of histamine.
Most likely new formulation: Targeted histamine receptor agonists/antagonists for specific conditions (2025, 70% confidence).
Based on current usage and safety profile, histamine's regulatory status is likely to remain stable (95% confidence).
Biogenic Amine, Autacoid
Imidazole