Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Apresoline
Hydralazine is a direct-acting vasodilator primarily used to treat high blood pressure (hypertension). It belongs to the class of vasodilators and works by relaxing the smooth muscles in the walls of arterioles, thereby reducing peripheral resistance and lowering blood pressure. It's often used in combination with other antihypertensive medications, especially in severe hypertension or hypertensive crises. It's also used to treat heart failure, particularly in combination with isosorbide dinitrate.
For treating high blood pressure and heart failure.
Outcome:
Decreased antihypertensive effect of hydralazine.
Mechanism:
Indomethacin can inhibit prostaglandin synthesis, which may counteract hydralazine's vasodilating effects.
Outcome:
Additive hypotensive effects.
Mechanism:
Both drugs lower blood pressure through different mechanisms.
Outcome:
Potential decreased absorption of hydralazine.
Mechanism:
Antacids can alter the pH of the stomach, potentially affecting hydralazine absorption.
Most likely new formulation: Extended-release oral formulation (Year: 2026, 70% confidence)
Based on current usage trends and safety profile, hydralazine is expected to maintain its current regulatory status with a 95% likelihood for the next 5 years.
Vasodilator, Antihypertensive
Hydrazinophthalazine