Medicines
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Discover all available medicines and treatments
Brand: Dilaudid, Exalgo, Palladone
Hydromorphone is a potent opioid analgesic used to treat moderate to severe pain. It is a semi-synthetic opioid derived from morphine and belongs to the opioid receptor agonist class. Hydromorphone binds to opioid receptors in the central nervous system, altering the perception of and response to pain.
For moderate to severe pain relief.
Hydromorphone carries a Black Box Warning for risks of addiction, abuse, misuse, life-threatening respiratory depression, neonatal opioid withdrawal syndrome, and risks from concomitant use with benzodiazepines or other CNS depressants.
Outcome:
Increased sedation, respiratory depression
Mechanism:
Additive CNS depression
Outcome:
Increased sedation
Mechanism:
Additive CNS depression
Outcome:
Slightly decreased hydromorphone absorption
Mechanism:
Altered GI absorption
Most likely new formulation: abuse-deterrent extended-release formulation (2024, 80% confidence)
Based on current opioid prescribing trends, there is a 70% likelihood of increased restrictions on hydromorphone prescriptions in the next 5 years.
Opioid Analgesic
Morphinan