Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Advil, Motrin, Nurofen, Midol, Children's Advil/Motrin
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and fever. It works by reducing hormones that cause inflammation and pain in the body. Ibuprofen is available over-the-counter (OTC) and by prescription.
For pain, fever, inflammation, and menstrual cramps.
Increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. Increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Outcome:
Increased bleeding risk
Mechanism:
Ibuprofen displaces warfarin from protein binding sites, increasing free warfarin levels.
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Synergistic effect on gastric mucosa irritation.
Outcome:
Drowsiness
Mechanism:
Additive sedative effects.
Most likely new formulation: topical ibuprofen with enhanced skin penetration (Year: 2025, 70% confidence)
Based on current usage trends and safety profile, ibuprofen is likely to maintain its approved OTC and prescription status.
Nonsteroidal Anti-inflammatory Drug (NSAID)
Propionic Acid Derivative