Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Crixivan
Indinavir is an antiretroviral medication used in the treatment of HIV infection. It belongs to a class of drugs called protease inhibitors, which work by blocking the activity of the HIV protease enzyme, essential for viral replication. By inhibiting this enzyme, indinavir prevents the virus from assembling new infectious particles, thus reducing the viral load in the body.
For the treatment of HIV infection in combination with other antiretroviral medications.
Outcome:
Decreased indinavir levels, potential treatment failure
Mechanism:
Induction of CYP3A4 enzyme
Outcome:
Increased indinavir and ketoconazole levels
Mechanism:
CYP3A4 inhibition
Outcome:
Slightly decreased indinavir absorption
Mechanism:
Chelation/altered gastric pH
Most likely new formulation: Generic formulations with improved bioavailability (Year: Unlikely, <1% confidence)
Based on historical usage patterns and declining prescription rates, there is a low (<5%) likelihood of new indications being pursued for indinavir.
Antiretroviral, Protease Inhibitor
Peptidomimetic