Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Indocin, Tivorbex
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation. It works by inhibiting the production of prostaglandins, which are chemicals involved in pain and inflammation. It is available in various formulations, including capsules, oral suspension, and suppositories. Indomethacin is a potent NSAID and is generally reserved for moderate to severe pain when other NSAIDs are ineffective.
For moderate to severe pain, inflammation, fever, and certain types of arthritis.
Indomethacin, like other NSAIDs, may increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. Indomethacin is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. Indomethacin, like other NSAIDs, can also increase the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events.
Outcome:
Increased risk of bleeding
Mechanism:
Indomethacin can displace warfarin from protein binding sites, increasing its free concentration.
Outcome:
Reduced antihypertensive effect
Mechanism:
NSAIDs can reduce the effectiveness of ACE inhibitors by inhibiting prostaglandin synthesis.
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Alcohol can irritate the GI tract.
Most likely new formulation: sustained-release injectable (Year: 2026, 70% confidence)
Based on usage patterns and adverse event reports, there is a 15% likelihood of stricter prescribing guidelines being implemented within the next 5 years.
Nonsteroidal Anti-inflammatory Drug (NSAID)
Acetic acid derivative