Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Nydrazid, Laniazid
Isoniazid is an antibiotic primarily used to treat tuberculosis (TB). It belongs to a class of drugs called hydrazides and works by inhibiting the synthesis of mycolic acids, essential components of the mycobacterial cell wall. Isoniazid is typically used in combination with other anti-TB drugs to prevent the development of drug resistance.
For the treatment of tuberculosis (TB).
Severe and sometimes fatal hepatitis associated with isoniazid therapy has been reported. The risk of developing hepatitis is age related. Hepatitis due to isoniazid has been reported to occur rarely in persons under the age of 20 years, in 0.3% to 0.5% of persons between the ages of 20 and 34 years, in 1.2% of persons between the ages of 35 and 49 years, and in 2.3% of persons aged 50 years or more.
Outcome:
Neurotoxicity (e.g., psychosis, seizures)
Mechanism:
Isoniazid inhibits the metabolism of disulfiram.
Outcome:
Decreased isoniazid absorption
Mechanism:
Antacids decrease the bioavailability of isoniazid.
Outcome:
Potential for hypertensive crisis
Mechanism:
Isoniazid can inhibit monoamine oxidase, leading to increased tyramine levels.
Most likely new formulation: Liposomal isoniazid for improved targeted delivery and reduced toxicity (Year 2026, 70% confidence)
Based on historical usage patterns and emerging resistance trends, there is a 15% likelihood of increased regulatory scrutiny regarding isoniazid prescription practices within the next 5 years.
Anti-tuberculosis Agent, Hydrazide
Hydrazide