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Brand: Imdur, Monoket, Ismo, Elantan, ISMO 20
Isosorbide-5-mononitrate is a long-acting nitrate vasodilator used to prevent angina pectoris (chest pain) in patients with coronary artery disease. It belongs to the class of organic nitrates and works by relaxing and widening blood vessels, improving blood flow to the heart. Unlike short-acting nitrates like nitroglycerin, it is designed for prophylactic use rather than acute angina relief.
Prevention of angina pectoris (chest pain) due to coronary artery disease.
Outcome:
Severe hypotension
Mechanism:
Additive vasodilatory effects
Outcome:
Additive hypotensive effects
Mechanism:
Synergistic effects on blood pressure
Outcome:
Enhanced antianginal effect
Mechanism:
Synergistic effects on platelet function and vasodilation
Most likely new formulation: extended-release combination with other antianginal agents (Year: 2026, 60% confidence)
Based on usage patterns and clinical trial data, there is a low ( <5%) likelihood of significant regulatory changes in the next 5 years.
Vasodilator, Antianginal
Organic Nitrate