Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Sporanox, Onmel, Tolsura
Itraconazole is a triazole antifungal medication used to treat a variety of fungal infections. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. This leads to changes in membrane permeability and ultimately fungal cell death. Itraconazole is available in both oral and intravenous formulations.
For the treatment of various fungal infections, including aspergillosis, blastomycosis, histoplasmosis, onychomycosis, and vaginal candidiasis.
Outcome:
Increased midazolam levels and risk of respiratory depression
Mechanism:
Inhibition of CYP3A4
Outcome:
Increased cyclosporine levels
Mechanism:
Inhibition of CYP3A4
Outcome:
Reduced itraconazole absorption
Mechanism:
Increased gastric pH
Most likely new formulation: Topical itraconazole for onychomycosis (2025, 80% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of itraconazole remaining a first-line treatment for onychomycosis over the next 5 years.
Antifungal, Triazole
Triazole