Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Coralan, Procoralan, Lancora, Bradia, Ivabrad, Ivabrine
Ivabradine is a medication used to treat stable symptomatic chronic heart failure and chronic stable angina pectoris. It works by selectively inhibiting the If current in the sinoatrial node, the heart's natural pacemaker, thereby slowing the heart rate. Ivabradine belongs to a class of drugs known as selective If current inhibitors. It offers an alternative treatment option for patients who cannot tolerate beta-blockers or for whom beta-blockers are insufficient to control their heart rate.
For the treatment of stable symptomatic chronic heart failure and chronic stable angina.
Outcome:
Increased ivabradine plasma levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Decreased ivabradine plasma levels
Mechanism:
CYP3A4 induction
Outcome:
No clinically significant interaction
Mechanism:
Different mechanisms of action
Most likely new formulation: Controlled-release formulation (Year 2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a 75% likelihood of ivabradine maintaining its current regulatory status for the next 5 years.
Selective If current inhibitor
Benzazepinone