Medicines
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Discover all available medicines and treatments
Brand: Kantrex, Kanamycin Sulfate Injection
Kanamycin is an aminoglycoside antibiotic used to treat serious bacterial infections, particularly those resistant to other antibiotics. It works by inhibiting protein synthesis in bacteria, leading to their death. It is effective against a wide range of gram-negative bacteria and some gram-positive bacteria. Due to its potential for serious side effects, including hearing loss and kidney damage, its use is generally reserved for severe infections when less toxic alternatives are unavailable or ineffective.
For the treatment of serious bacterial infections, particularly those resistant to other antibiotics.
Kanamycin can cause serious side effects, including irreversible hearing loss (ototoxicity) and kidney damage (nephrotoxicity). These side effects are more likely to occur with prolonged use or in patients with pre-existing kidney problems. Patients should be closely monitored for signs of hearing loss and kidney dysfunction during treatment.
Outcome:
Increased risk of nephrotoxicity and ototoxicity
Mechanism:
Additive renal and auditory toxicities
Outcome:
Increased risk of nephrotoxicity
Mechanism:
Additive nephrotoxicity
Outcome:
Reduced kanamycin absorption
Mechanism:
Chelation or binding in the GI tract
Most likely new formulation: Liposomal kanamycin for reduced toxicity (Year: 2026, 70% confidence)
Based on historical usage patterns and emerging resistance data, there is a 25% likelihood of increased restrictions on kanamycin use within the next 5 years.
Aminoglycoside Antibiotic
Aminoglycoside