Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Ketalar, Ketaset, Spravato
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia, as well as for the treatment of depression and chronic pain. It acts primarily as an NMDA receptor antagonist, but also interacts with other receptors in the brain. It can produce a trance-like state while providing pain relief, sedation, and amnesia.
Used for anesthesia, treatment-resistant depression, and chronic pain management.
Ketamine can cause emergence reactions, including hallucinations, confusion, and irrational behavior. It should be administered in a controlled setting with appropriate monitoring.
Outcome:
Respiratory depression, increased sedation
Mechanism:
Additive CNS depressant effects
Outcome:
Increased sedation
Mechanism:
Additive CNS depressant effects
Outcome:
Potentially increased ketamine levels
Mechanism:
Inhibition of CYP3A4 enzyme
Most likely new formulation: Extended-release oral ketamine for chronic pain (Year 2025, 80% confidence)
Based on increasing off-label use for depression, there is a 70% likelihood of expanded FDA indications in the next 5 years.
Dissociative Anesthetic, NMDA Receptor Antagonist
Arylcyclohexylamine