Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Toradol, Acular, Sprix, Ketorolaco
Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) used for short-term management of moderately severe acute pain. It works by inhibiting the production of prostaglandins, which are involved in pain and inflammation. Ketorolac is available in various formulations, including oral, intramuscular, intravenous, and ophthalmic solutions.
For the short-term management of moderately severe acute pain.
Ketorolac is contraindicated in patients with active peptic ulcer disease, recent gastrointestinal bleeding or perforation, advanced renal impairment, cerebrovascular bleeding, hemorrhagic diathesis, incomplete hemostasis, and those at high risk of bleeding. It should not be used concurrently with other NSAIDs, including aspirin, and should only be used for short-term (up to 5 days total) management of pain due to an increased risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation.
Outcome:
Increased bleeding risk
Mechanism:
Ketorolac can displace warfarin from protein binding sites, increasing its free concentration.
Outcome:
Increased risk of GI bleeding
Mechanism:
Additive irritant effects on the gastric mucosa.
Outcome:
Reduced ketorolac absorption
Mechanism:
Antacids can alter gastric pH, affecting drug absorption.
Most likely new formulation: extended-release oral formulation (2025, 60% confidence)
Based on current usage patterns and safety profile, there is a low ( <5%) likelihood of ketorolac being withdrawn from the market in the next 5 years.
Nonsteroidal anti-inflammatory drug (NSAID)
Pyrrolo-pyrrole acetic acid