Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Trandate, Normodyne
Labetalol is a dual-action alpha and beta-adrenergic receptor blocker used to treat high blood pressure (hypertension). It works by blocking both types of receptors, leading to relaxation of blood vessels and a decrease in heart rate, which lowers blood pressure. Labetalol is available in both oral and intravenous formulations and belongs to the class of combined alpha and beta blockers.
For treating high blood pressure (hypertension), including hypertensive emergencies and pregnancy-induced hypertension.
Outcome:
Increased labetalol levels
Mechanism:
Inhibition of labetalol metabolism
Outcome:
Increased bradycardia
Mechanism:
Additive effects on heart rate
Outcome:
Reduced labetalol absorption
Mechanism:
Altered gastrointestinal pH
Most likely new formulation: Controlled-release labetalol (2025, 30% confidence)
Based on current usage trends and clinical trial data, there is a low probability ( <5%) of any major regulatory changes to labetalol's FDA approval status within the next 5 years.
Alpha and Beta Blocker
Benzamide derivative