Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Lamictal, Subvenite, Lafigin, Lamitor, Epimil
Lamotrigine is an anticonvulsant medication used primarily to treat epilepsy and bipolar disorder. It belongs to the phenyltriazine class and works by stabilizing neuronal membranes and inhibiting the release of excitatory neurotransmitters like glutamate, thus reducing the occurrence of seizures. In bipolar disorder, it is primarily used for maintenance treatment and helps prevent mood episodes, particularly depressive episodes.
Used to treat epilepsy and bipolar disorder.
Serious skin rashes requiring hospitalization, including life-threatening Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported. The risk of these reactions is increased in children younger than 2 years. Patients should be monitored closely for skin rashes, especially during the first 8 weeks of therapy. Lamotrigine should be discontinued at the first sign of rash, unless the rash is clearly unrelated to the drug.
Outcome:
Increased lamotrigine levels (can lead to toxicity)
Mechanism:
Valproic acid inhibits lamotrigine metabolism.
Outcome:
Slightly decreased lamotrigine levels
Mechanism:
May slightly induce lamotrigine metabolism.
Outcome:
May slightly decrease lamotrigine absorption
Mechanism:
Altered gastrointestinal pH
Most likely new formulation: Extended-release lamotrigine for improved patient compliance (Year: 2025, 80% confidence).
Based on current usage trends and clinical trial data, there is a 70% likelihood of lamotrigine being approved for a new indication related to migraine prevention within the next 5 years.
Anticonvulsant, Mood Stabilizer
Phenyltriazine