Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Nozinan, Levoprome, Neurocil
Levomepromazine is a phenothiazine antipsychotic with sedative, anxiolytic, and antiemetic properties. It belongs to the class of typical antipsychotics and acts primarily by blocking dopamine D2 receptors in the brain. It is also an antagonist of histamine H1, muscarinic, and alpha-adrenergic receptors, which contributes to its sedative and other effects. Levomepromazine is used to treat various psychiatric conditions, particularly in cases where sedation is beneficial.
Used to treat psychosis, anxiety, and insomnia, and as an antiemetic.
Outcome:
Increased sedation and respiratory depression
Mechanism:
Additive CNS depressant effects
Outcome:
Increased risk of hypotension
Mechanism:
Additive hypotensive effects
Outcome:
Slightly reduced effectiveness of levomepromazine
Mechanism:
CNS stimulation
Most likely new formulation: Extended-release formulation to improve adherence (Year: 2026, 30% confidence)
Based on historical data and current usage trends, there is a low probability (<5%) of levomepromazine receiving FDA approval in the next 5 years.
Antipsychotic, Phenothiazine
Phenothiazine