Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Dopergin, Cuvalit, Lysenyl, Proclacam
Lisuride is a semisynthetic ergot derivative with dopamine agonist and serotonin antagonist properties. It primarily affects dopamine receptors in the brain, mimicking the effects of dopamine. This action makes it useful in treating conditions like Parkinson's disease and other neurological disorders. Lisuride is also known for its efficacy in managing migraine headaches and cyclical breast pain. It has historically been used for other conditions, but its use has become less common due to newer, safer alternatives.
Used for Parkinson's disease, migraine prophylaxis, and cyclical mastalgia (breast pain).
Outcome:
Reduced effectiveness of lisuride
Mechanism:
Competitive antagonism at dopamine receptors
Outcome:
Decreased lisuride efficacy
Mechanism:
Dopamine receptor antagonism
Outcome:
Slightly decreased lisuride absorption
Mechanism:
Changes in gastric pH
Most likely new formulation: Transdermal patch for improved delivery and patient compliance (Year: 2026, 20% confidence)
Based on historical usage patterns and the availability of newer treatments, there is a low (<10%) likelihood of lisuride being approved by the FDA in the near future.
Dopamine agonist, Serotonin antagonist
Ergot alkaloid derivative