Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: CeeNU, Gleostine
Lomustine is an alkylating agent used as chemotherapy to treat certain types of brain tumors, including glioblastoma, medulloblastoma, and astrocytoma. It belongs to the nitrosourea class of drugs and works by interfering with DNA replication and repair in cancer cells, ultimately leading to cell death. Lomustine is administered orally and is known for its ability to cross the blood-brain barrier, making it effective in treating brain cancers.
Used to treat brain tumors such as glioblastoma, medulloblastoma, and astrocytoma.
Severe bone marrow suppression including prolonged pancytopenia and increased risk of infections and bleeding. Pulmonary toxicity, including interstitial pneumonitis and fibrosis, can occur and be fatal. Hepatotoxicity, including liver failure, can occur. Secondary malignancies, including acute leukemia and myelodysplastic syndrome, have been reported.
Outcome:
Increased lomustine toxicity
Mechanism:
Reduced hepatic metabolism of lomustine.
Outcome:
Altered lomustine levels
Mechanism:
Potential for enzyme induction or inhibition.
Outcome:
Potentially reduced lomustine absorption
Mechanism:
Changes in stomach pH.
Most likely new formulation: nanoparticle delivery system for improved efficacy and reduced toxicity (2028, 30% confidence)
Based on historical approval rates for similar drugs, there is a low (<10%) likelihood of new indications being approved in the next 5 years.
Alkylating agent, Nitrosourea
Nitrosourea