Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Imodium, Diamode, Loperamide HCl, Imodium A-D, Kaopectate II Caplets
Loperamide is an antidiarrheal medication used to treat acute and chronic diarrhea. It belongs to the class of opioid receptor agonists but does not cross the blood-brain barrier in significant amounts at recommended doses, thus lacking opioid-like euphoric effects. It works by slowing down intestinal motility, allowing for increased water and electrolyte absorption.
For the treatment of diarrhea, including traveler's diarrhea and diarrhea associated with irritable bowel syndrome.
Outcome:
Increased loperamide levels, risk of cardiac events
Mechanism:
Inhibition of P-glycoprotein
Outcome:
Increased loperamide levels
Mechanism:
Inhibition of P-glycoprotein
Outcome:
Slightly decreased loperamide absorption
Mechanism:
Altered gastric pH
Most likely new formulation: sustained-release formulation for improved adherence (Year 2026, 60% confidence)
Based on consistent usage and safety profile, there is a <1% likelihood of regulatory changes impacting OTC status in the next 5 years.
Antidiarrheal, Opioid Receptor Agonist
Phenylpiperidine derivative