Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Loxitane, Adasuve
Loxapine is an antipsychotic medication primarily used to treat schizophrenia. It belongs to the dibenzoxazepine class of chemical compounds and is structurally similar to clozapine. Loxapine works by affecting the balance of neurotransmitters (specifically dopamine, serotonin, norepinephrine, histamine, and acetylcholine) in the brain. It exists in two forms: loxapine succinate (the conventional formulation) and loxapine inhalation powder (for acute agitation).
For the treatment of schizophrenia and acute agitation.
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Loxapine is not approved for the treatment of patients with dementia-related psychosis.
Outcome:
Increased sedation, respiratory depression
Mechanism:
Additive CNS depressant effects
Outcome:
Decreased loxapine levels
Mechanism:
Induction of CYP1A2 metabolism
Outcome:
Increased loxapine absorption
Mechanism:
Enhanced bioavailability
Most likely new formulation: Extended-release oral formulation (Year: 2025, 60% confidence)
Based on current usage trends and clinical trial data, there is a low (<5%) likelihood of a major regulatory change in the next 2 years.
Antipsychotic, Dibenzoxazepine
Dibenzoxazepine