Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Madopar, Prolopa
Madopar is a combination medication used to treat Parkinson's disease. It contains levodopa, a precursor to dopamine, and benserazide, a peripheral decarboxylase inhibitor. Parkinson's disease is characterized by a deficiency of dopamine in the brain. Levodopa replenishes this dopamine, while benserazide prevents its premature breakdown outside the brain, allowing more levodopa to reach the brain and be converted to dopamine. This improves motor control and reduces symptoms like tremors and rigidity.
For treating Parkinson's disease symptoms, such as tremors, rigidity, and slow movement.
Outcome:
Hypertensive crisis
Mechanism:
Increased catecholamine levels
Outcome:
May increase levodopa's effects and side effects
Mechanism:
Dopamine receptor antagonist
Outcome:
Delayed and reduced absorption of levodopa
Mechanism:
Competition for absorption in the gut
Most likely new formulation: Extended-release levodopa/benserazide combination with improved bioavailability (Year: 2025, 60% confidence)
Based on current usage trends and clinical trial data, Madopar's generic formulations are expected to maintain a significant market share (70% likelihood) over the next 5 years.
Antiparkinson Agent, Dopamine Precursor
Substituted Hydrazine, Amino Acid Derivative