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Brand: Osmitrol, Resectisol, Mannitol Injection, Mannitol Solution
Mannitol is an osmotic diuretic primarily used to reduce intracranial pressure and treat acute glaucoma. It's classified as a sugar alcohol and works by increasing the osmolarity of blood and other fluids, drawing water out of tissues like the brain and eyes. It's also used to promote diuresis in certain conditions like kidney failure.
Used to reduce intracranial pressure, treat acute glaucoma, and promote diuresis in certain conditions.
Outcome:
Increased risk of digoxin toxicity
Mechanism:
Mannitol-induced electrolyte imbalances can enhance digoxin effects.
Outcome:
Decreased diuretic effect of mannitol
Mechanism:
NSAIDs can reduce renal blood flow, affecting mannitol's action.
Outcome:
Increased diuretic effect
Mechanism:
Caffeine also has diuretic properties.
Most likely new formulation: sustained-release for longer-term management of elevated ICP (Year: 2028, 30% confidence)
Based on current usage trends and clinical trial activity, there is a low (5%) likelihood of any major regulatory changes for mannitol in the next 5 years.
Osmotic Diuretic
Sugar Alcohol