Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Lariam, Mephaquin
Mefloquine is an antimalarial drug used to prevent or treat malaria caused by the parasite Plasmodium falciparum. It belongs to the quinoline-methanol class of drugs and works by interfering with the parasite's growth within red blood cells. Mefloquine is typically used for travelers to areas where malaria is common.
For the prevention and treatment of malaria caused by Plasmodium falciparum.
Mefloquine may cause serious neuropsychiatric reactions, including anxiety, paranoia, hallucinations, depression, and suicidal thoughts. These reactions can occur during use or up to months after discontinuation. Patients should be monitored for these effects.
Outcome:
Increased risk of cardiac arrhythmias
Mechanism:
Both drugs prolong the QT interval
Outcome:
Increased risk of bradycardia
Mechanism:
Additive effects on heart rate
Outcome:
Increased risk of anxiety
Mechanism:
Additive stimulant effects
Most likely new formulation: Liposomal mefloquine for improved tolerability and efficacy (2025, 60% confidence)
Based on current usage trends and emerging resistance patterns, there is a 20% likelihood of increased restrictions on mefloquine use in the next 5 years.
Antimalarial
Quinoline-methanol