Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Megace, Megace ES
Megestrol acetate is a synthetic progestin, a hormone similar to progesterone. It is primarily used to stimulate appetite and weight gain in individuals experiencing anorexia, cachexia, or unexplained weight loss, particularly in patients with AIDS or cancer. It can also be used to treat breast and endometrial cancer. Megestrol works by affecting hormone levels in the body.
Used to treat loss of appetite and weight loss, particularly in patients with AIDS or cancer, and to treat breast and endometrial cancer.
Outcome:
Increased megestrol levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Increased megestrol levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
May decrease megestrol effectiveness
Mechanism:
Unknown
Most likely new formulation: Extended-release oral suspension (Year: 2025, 60% confidence)
Based on current usage trends and clinical trial data, there is a low (<5%) likelihood of significant regulatory changes in the next 2 years.
Antineoplastic, Progestin
Steroid