Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Namenda, Ebixa, Axura, Akatinol
Memantine is an NMDA receptor antagonist used primarily to treat moderate to severe Alzheimer's disease. It works by regulating the activity of glutamate, a neurotransmitter involved in learning and memory, which is believed to be overactive in Alzheimer's patients, contributing to neuronal damage. Memantine belongs to the class of drugs known as uncompetitive NMDA receptor antagonists and offers a unique mechanism compared to other Alzheimer's medications like cholinesterase inhibitors.
For moderate to severe Alzheimer's disease.
Outcome:
Increased risk of adverse effects (e.g., confusion, hallucinations)
Mechanism:
Additive anticholinergic effects
Outcome:
Slightly increased memantine levels
Mechanism:
Reduced renal clearance
Outcome:
No clinically significant interaction expected
Mechanism:
Different mechanisms of action
Most likely new formulation: Extended-release formulation to improve patient compliance (2025, 70% confidence).
Based on current usage trends and clinical trial data, there is a low (5%) likelihood of any major regulatory changes for memantine in the next 5 years.
NMDA Receptor Antagonist
Adamantane Derivative