Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Glucophage, Glumetza, Fortamet, Riomet, Glucophage XR, Obimet, Dianben, Metfogamma
Metformin is a first-line medication for type 2 diabetes, belonging to the biguanide class. It works primarily by reducing hepatic glucose production and improving insulin sensitivity in peripheral tissues. It does not typically cause hypoglycemia when used as monotherapy. Metformin can also be used off-label for polycystic ovary syndrome (PCOS) and prediabetes.
For the treatment of type 2 diabetes, sometimes used for prediabetes and polycystic ovary syndrome (PCOS).
Outcome:
Lactic acidosis
Mechanism:
Reduced renal clearance of metformin
Outcome:
Increased risk of dehydration and adverse effects
Mechanism:
Additive diuretic effect
Outcome:
Minor increase in metformin levels
Mechanism:
Slight reduction in renal clearance
Most likely new formulation: extended-release combination with other antidiabetic agents (2025, 80% confidence)
Based on consistent usage and safety data, metformin is expected to remain a first-line treatment for type 2 diabetes with a 95% likelihood of continued FDA approval.
Antidiabetic, Biguanide
Biguanide