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Brand: Brevital
Methohexital is a barbiturate used as a general anesthetic for short surgical procedures and for inducing anesthesia. It is a short-acting drug that produces rapid onset and recovery of consciousness. Belonging to the barbiturate class, it acts by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system, leading to decreased neuronal activity.
For inducing and maintaining general anesthesia for short surgical, diagnostic, or therapeutic procedures.
Outcome:
Increased sedation and respiratory depression
Mechanism:
Additive CNS depressant effects
Outcome:
Increased methohexital levels
Mechanism:
Inhibition of methohexital metabolism
Outcome:
Mildly increased sedation
Mechanism:
Additive CNS depressant effects
Most likely new formulation: None anticipated in the near future (2024-2028, 90% confidence).
Based on current usage patterns and safety profile, methohexital's approved status is likely to remain stable (95% confidence).
Barbiturate, General Anesthetic
Barbiturate