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Brand: Fomepizole
4-Methylpyrazole (4-MP) is an alcohol dehydrogenase inhibitor primarily used in the treatment of methanol and ethylene glycol poisoning. It works by preventing the metabolism of these toxic alcohols into harmful byproducts like formic acid and oxalic acid. 4-MP belongs to the class of pyrazoles and is administered intravenously.
For the treatment of methanol and ethylene glycol poisoning.
Outcome:
Increased risk of ethanol toxicity
Mechanism:
Competition for alcohol dehydrogenase
Outcome:
Altered anticoagulant effect
Mechanism:
Potential interaction with CYP450 enzymes
Outcome:
Potential for additive gastrointestinal effects
Mechanism:
Both can cause GI irritation
Most likely new formulation: extended-release injectable (Year: 2026, 70% confidence)
Based on current usage patterns and adverse event reports, the likelihood of a black box warning being issued within the next 5 years is low (<1%).
Alcohol Dehydrogenase Inhibitor
Pyrazole