Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Lopressor, Toprol XL, Betaloc, Seloken, Lopresor SR
Metoprolol is a beta-blocker, a type of medication that primarily affects the heart and blood vessels. It works by blocking the effects of the hormone epinephrine (adrenaline), leading to a slower heart rate, decreased blood pressure, and reduced workload on the heart. It exists in two main forms: metoprolol tartrate (immediate-release) and metoprolol succinate (extended-release). The immediate-release form is typically used for angina and high blood pressure, while the extended-release version is usually prescribed for hypertension, heart failure, and heart attack prevention.
For high blood pressure, angina (chest pain), heart failure, and to prevent heart attacks.
Outcome:
Increased risk of bradycardia
Mechanism:
Additive effects on heart rate
Outcome:
Reduced antihypertensive effect
Mechanism:
NSAIDs can reduce the effectiveness of beta-blockers
Outcome:
Slight reduction in metoprolol effect
Mechanism:
Caffeine can slightly counteract the effects of beta-blockers
Most likely new formulation: extended-release combination with another antihypertensive agent (2025, 70% confidence)
Based on usage patterns and clinical trial data, there is a low ( <5%) likelihood of new black box warnings being issued within the next 5 years.
Beta-adrenergic blocking agent, Antihypertensive, Antianginal
Aryloxypropanolamine