Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Tolvon, Bolvidon, Norval
Mianserin is a tetracyclic antidepressant used to treat major depressive disorder. It affects certain chemical messengers in the brain that may become unbalanced, leading to depression. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) due to its unique mechanism of action, which involves antagonism of alpha2-adrenergic receptors, leading to increased noradrenaline and serotonin release. Mianserin does not inhibit serotonin reuptake like many other antidepressants, which may contribute to its different side effect profile.
For the treatment of major depressive disorder.
Outcome:
Increased sedation and impaired coordination.
Mechanism:
Additive CNS depressant effects.
Outcome:
Increased mianserin levels.
Mechanism:
Inhibition of mianserin metabolism.
Outcome:
Slightly decreased mianserin efficacy.
Mechanism:
Caffeine's stimulant effects may counteract mianserin's sedative properties.
Most likely new formulation: Extended-release formulation (Year 2028, 30% confidence)
Based on historical data and current research trends, the likelihood of FDA approval for mianserin in the near future is low.
Tetracyclic antidepressant, NaSSA (Noradrenergic and Specific Serotonergic Antidepressant)
Piperazinoazepine