Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: ProAmatine, Orvaten
Midodrine is a prodrug that is metabolized to desglymidodrine, a selective alpha1-adrenergic agonist. It acts primarily on the alpha1-adrenergic receptors of arterioles and veins, leading to vasoconstriction and an increase in peripheral vascular resistance. This action helps to raise blood pressure in patients with orthostatic hypotension, a condition characterized by a drop in blood pressure upon standing.
For the treatment of symptomatic orthostatic hypotension.
Outcome:
Increased risk of bradycardia
Mechanism:
Additive effects on heart rate
Outcome:
Increased risk of orthostatic hypotension
Mechanism:
Reduced blood volume
Outcome:
Reduced absorption of midodrine
Mechanism:
Altered gastric pH
Most likely new formulation: Extended-release formulation (Year: 2026, 30% confidence)
Based on current usage trends and ongoing research, there is a low ( < 10%) likelihood of a major regulatory change for midodrine in the next 5 years.
Alpha-1 adrenergic agonist, Vasopressor
Imidazoline