Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Savella, Ixel
Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) primarily used to treat fibromyalgia. It works by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain that play a role in mood regulation, pain perception, and sleep. It is also used in some countries for the treatment of major depressive disorder.
For the treatment of fibromyalgia and, in some countries, major depressive disorder.
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Increased sedation
Mechanism:
Additive CNS depressant effects
Most likely new formulation: Extended-release formulation (Year: 2026, 60% confidence)
Based on current usage patterns and clinical trial data, there is a low likelihood of any major regulatory changes for milnacipran in the next 2 years (less than 10% probability).
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Cyclopropanecarboxamide