Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Lysodren
Mitotane is an antineoplastic drug specifically designed to treat adrenocortical carcinoma (ACC), a rare cancer of the adrenal cortex. It's classified as a cytotoxic agent, meaning it works by directly killing cancer cells. Mitotane acts by suppressing the adrenal cortex, inhibiting steroidogenesis, and causing selective necrosis of adrenocortical tumor cells.
For the treatment of inoperable adrenocortical carcinoma (ACC).
Outcome:
Increased risk of bleeding
Mechanism:
Mitotane can induce hepatic enzymes, increasing warfarin metabolism.
Outcome:
Increased mitotane levels
Mechanism:
Inhibition of CYP3A4 metabolism.
Outcome:
Increased mitotane absorption
Mechanism:
Enhanced solubility and bioavailability.
Most likely new formulation: sustained-release mitotane for improved patient compliance (Year: 2026, 80% confidence)
Based on current usage trends and ongoing clinical trials, there is a 70% likelihood of expanded indications for mitotane in the treatment of other adrenal disorders within the next 5 years.
Antineoplastic, Cytotoxic Agent, Adrenolytic
Dichlorodiphenyldichloroethane (DDD) analog